Mathematical model of the hydrolization of PIP2 with the stimulation of EGF
- VernacularTitle:EGF刺激下PIP_2水解的数学模型
- Author:
Yongchun SU
;
Qinkai DENG
;
Shenqiu LUO
;
Fan DENG
;
Di LU
;
Xiaochun BAI
- Publication Type:Journal Article
- Keywords:
PIP 2;
mathematical model;
dynamics
- From:
Chinese Medical Equipment Journal
1989;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate dynamic characteristics of the hydrolization lipid phosphatidylinositol(4,5)-bisphosphate(PIP 2 )with the stimulation of epidermal growth factor(EGF),the mathematical model to simulate the metabolizability of PIP 2 is established based on Law of Mass Action and Law of the Quasi-steady-State Approximation.Differential equations of concentration relations between PIP 2 and EGF receptor are formulated,and the effect of the parameters on the changing trend of PIP 2 is analyzed.This mathematical model describes biology characteristics of metabolized PIP 2 and dependency relationships of concentration between key signal producuts.
