The experimental study on relationship between the brain ischemic tolerance and neuronal apoptosis and expression of p53,p21 and Bax
- VernacularTitle:脑缺血耐受与细胞凋亡及p53、p21、Bax表达关系的实验研究
- Author:
Daowen CHEN
;
Yong ZHOU
;
Xuexu ZHAO
- Publication Type:Journal Article
- Keywords:
Ischemic preconditioning Ischemic tolerance Apoptosis p53 p21 Bax
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of apoptosis and apoptotic proteins p53,p21 and Bax in mechanisms of brain ischemic tolerance in rats.Methods In our study the models of focal-focal type brain ischemic preconditioning were maded by occlusion middle cerebral artery using an intraluminal filament method. Infarct sizes were measured by image analysis system.Neuronal apoptosis was identified by TUNEL staining and expressions of p53, p21 and Bax were analyzed by immunohistochemistry.Results Compared with the lethal ischemic group, the volume of infarct was greatly reduced when MCAO 20 minutes was performed as ischemic preconditioning( P
