The expression of tumor necrosis factor-alpha and intracellular adhesion molecular-1 in cerebral tissue after experimental intracerebral hemorrhage in rats
- VernacularTitle:大鼠实验性脑出血后脑组织肿瘤坏死因子-?、细胞间黏附分子-1的表达
- Author:
Zhiming ZHOU
;
Jiasong GE
;
Shengda LIU
- Publication Type:Journal Article
- Keywords:
Intracerebral hemorrhage Tumor necrosis factor alpha Intracellular adhesion molecular-1
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of tumor necrosis factor-?(TNF-?) and intracellular adhesion molecular-1(ICAM-1) in brain tissue after experimental intracerebral hemorrhage in rats.Methods Experimental intracerebral hemorrhage model was maded by injection autologous blood using stereotactic method. The expression of TNF-? and ICAM-1 in cerebral tissues at different time were detected by using immunohistochemitry techniques.Results TNF-? expression raised obviously at 6 h and peaked at 48 h.ICAM-1 expression raised obviously at 12 h and peaked at 72 h.There was obvious difference between each intracerebral hemorrhage group and controls(all P
