Experimental Research and Clinical Observation of Circadian R hythm on Pharmacodynamics of Lidocain Alkalified Solution
10.3870/j.issn.1004-0781.2001.04.049
- VernacularTitle:时辰对利多卡因碱化液药效影响的实验及临床观察
- Author:
Dunyi HU
;
Hui WANG
- Publication Type:Journal Article
- From:
Herald of Medicine
2001;(4):261-
- CountryChina
- Language:Chinese
-
Abstract:
To explore the time-dependent of p harmacodynamics of lidocain alkalified solution. Method: On 8:00 am and 8:00 pm, surface anaesthesia and subarachnoid anaesthesia were con ducted in rabbits and 76 cases of surgical patients receiving epidureal anaesthe sia were observed in therapy effect.Results: The results of animal experimental showed the anaesthesia potency and anaesthesia incubatory period were better on 8:00 am than 8:00 pm; the clinical observation also obtain ed asimilar result. Conclusion: These results showed that lidocain alkalified solution had time-dependent of pharmacodynamics.
