Study of relationship between sulfonylurea receptor gene polymorphism and type 2 diabetes
- VernacularTitle:磺脲类药物受体基因多态性和2型糖尿病相关性研究
- Author:
Ming ZHAO
;
Hong DU
;
Yanyan WANG
;
Jian WANG
- Publication Type:Journal Article
- Keywords:
Sulfonylurea receptor;
Diabetes mellitus;
Gene
- From:
Journal of Medical Postgraduates
2004;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore relationship between sulfonylurea receptor gene polymorphism and type 2 diabetes mellitus in Chinese subjects. Methods: Polymorphism of exon 16-3T→C in SUR gene 1 in 155 type 2 diabetic subjects and 132 controls were assessed by restriction fragment length polymorphism. Results: Frequency of “C” allele and “CC” homozygous phenotype in type 2 diabetic subjects was higher than that in control group. Conclusion:Allele “C” stands for hereditary susceptibility to diabetes.
