The Influences of Immune Suspression by Oral Administration of Type Ⅱ Collagen on Rat Rheumatic Osteoarthritis and Traumatic Osteoarthritis
- VernacularTitle:口服Ⅱ型胶原诱导免疫耐受对大鼠类风湿性关节炎和创伤性骨性关节炎的影响
- Author:
Jie SUN
;
Changlong YU
- Publication Type:Journal Article
- Keywords:
traumatic osteoarthritis, rheumatic arthritis, type Ⅱ collagen, immune suspression
- From:Chinese Journal of Sports Medicine
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Purpose: To study the influences of immune suspression by oral administration of type Ⅱ collagen on the pathogenesis of collagen induced arthritis(CIA) and traumatic oseoarthritis(OA) in rats; Methods: Rat knee traumatic osteoarthritis model made by excision of medial collateral ligament and medial meniscetomy and CIA model were applied for the observation of the changes on hisological and histochemical staining and the inhibition of T cells after oral administration of type Ⅱ collagen. Results: In OA, although the T cells were suspressed by oral administration of type Ⅱ collagen, however, the the pathogenesis was not hindered comparing with RA. It indicated that for OA, machanical factor is more important than the immunological factor, oral administration of type Ⅱ collagen has little effect on decreasing the speed of development of OA. It is not adequate to take the remedy of oral administation of type Ⅱ collagen for the treatment of OA.
