Minimal and optimal concentration of ropivacaine for epidural anesthesia in mastectomy
10.3760/cma.j.issn.1006-9801.2013.03.016
- VernacularTitle:乳腺癌硬膜外麻醉中罗哌卡因最低有效浓度和最佳浓度的临床研究
- Author:
Gang YIN
;
Yishu LIU
;
Shuming ZHANG
;
Ming YU
;
Qixiang SHEN
- Publication Type:Journal Article
- Keywords:
Ropivacaine;
Breast neoplasms;
Anesthesia,epidural
- From:
Cancer Research and Clinic
2013;(3):195-197,213
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the minimal and optimal concentration of ropivacain for epidural anesthesia in patients with breast cancer.Methods 103 patients with breast cancer ASA Ⅰ-Ⅱ undergoing elective radical mastectomy were conducted with epidural anesthesia.T2-3 were selected as a puncture site.A catheter was inserted into the epidural space in a cephalic direction for 3.5-4.0 cm.The concentration of ropivacain was produced by the test of up-down sequential allocation technique.20-25 ml of 0.20 ％ ropivacaine was given after a test of 0.20 ％ 5 ml ropivacaine.If the anesthesia was effective (VAS≤3),the next concentration was down 0.01％,while the VAS was more than 5,the next concentration was up 0.01％.The anesthesia effect and segments of block were measured with acupuncture.Blood pressure (NIBP),heart rates(HR),blood oxygen saturation (SPO2),blood gas and VAS were monitored during operation.Nasal catheter oxygen inhalation was used in routine method.Results The median effective concentration (EC50) of ropivacaine was 0.10 ％ determined by the formula of dixon and massey.The 95 ％ confidence intervals was 0.1022 ％-0.1065 ％.The least and the best analgesic concentration of ropivacaine for the upper thoracic epidural block was 0.14 ％ and 0.17 ％-0.18 ％ respectively.Conclusion The minimal and the optimal analgesic concentration of ropivacaine for the upper thoracic epidural block are 0.14 ％ and 0.17 ％-0.18 ％respectively,and which provides a safe and rational use of ropivacaine for the clinic.
