Effect of Granulocyte (-Macrophage) Colony-Stimulating Factor on Oral Mucositis Due to Concomitant Chemoradiotherapy in Locally Advanced Head and Neck Cancer Patients
- VernacularTitle:G(M)-CSF治疗放化疗引起的口腔黏膜炎的临床观察
- Author:
Qinghua DENG
;
Yuan ZHU
;
Peng HU
;
Shenglin MA
- Publication Type:Journal Article
- Keywords:
G(M)-CSF;
oral mucositis;
head and neck cancer;
concomitant chemoradiotherapy
- From:
Chinese Journal of Cancer Biotherapy
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the efficacy of granulocyte(-macrophage) colony stimulating factor[G(M)-CSF] inthe treatment of concomitant chemoradiotherapy-induced oral mucositis in locally advanced head and neck cancer patients.Metheds: Fifteen patients with locally advanced head and neck cancer was received concomitant chemoradiotherapy, whilewhite blood cell count were less than 1. 5?10~9/L with grade Ⅲ/Ⅳ oral mucositis, they were subcutaneously given G(M)-CSF at dose of 100-300?g daily for 3～10 days. Results: After administration of G(M)-CSF, all of the patients had anaugmantation of white blood cell count more than 5. 0?10~9/L. Complete healing of oral mucositis occurred in 1 patient(CR), partial in 8 patients(PR), whereas 6 patients had no change and none was progressive, the objective response rate(CR+PR) was 60%. Condusions: G(M)-CSF is proved effective for oral mucositis caused by concomitant chemoradio-therapy in locally advanced head and neck cancer patients.
