Restoration of endothelial function after reperfusio injury by tetrahydrobiopterin
- VernacularTitle:四氢喋呤对兔缺血再灌注损伤内皮功能的保护作用
- Author:
Jianhui TIAN
;
Shan LI
;
Chengjun LIU
- Publication Type:Journal Article
- Keywords:
Tetrahydrobiopterin;
Reperfusion injury;
Nitric oxide
- From:
Chinese Journal of Interventional Cardiology
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the influence of tetrahydrobiopterin on NO and MDA concentration and SOD activity as well as the myocardial infarction area. Methods Twenty-four rabbits were divided into three groups randomly: control group,MI/R group and BH 4 group. After occlusion of the left anterior descending coronary artery of a rabbit for 60 minutes followed by 90 minutes of reperfusion (ischemia/reperfusion),NO and MDA and SOD concentrations were measured and the myocardial infarction area was caculated. Results Compared with control group,the NO concentration in MI/R group was markedly decreased [(28?10) ?mol/L vs (116?17) ?mol/L,P 0.05];There was significant difference between MI/R and BH 4 groups in infarction area,too. [(18?4)% vs (16?4)%,P
