Influence of Restraint Stress on the Immune Function of Mice with S180 Tumor
- VernacularTitle:束缚应激对S180荷瘤小鼠免疫功能的影响
- Author:
Wenjie WANG
;
Ji WANG
;
Miu ZHAO
- Publication Type:Journal Article
- Keywords:
oncology restraint stress animal studies immune function
- From:
Chinese Mental Health Journal
2002;0(12):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of restraint stress on T, B lymphocyte transformation rate and phagocytic function of peritoneal macrophage.Method:Cells were extracted from the abdominal cavity of mice with S180 tumor and then were injected subcutaneously in the right oxter in 0.2 ml/mouse. Some of the mice were bound at the same time. There were four groups in all, they were normal control, tumor mice without restrain, restrained mice without tumor, and mice with both tumor cell injection and restrain. All mice were killed after 10 days, T and B lymphocyte transformation rates of spleen were examined, the phagocytic function of peritoneal macrophage was also tested. The weights of tumors were also recorded.Result:Compared with tumor mice without restrain, the mice with both tumor injection and restrain had lower T, B lymphocyte transformation rates and lower phagocytic function of peritoneal macrophage. The weight of tumor in the study group was also higher than that of tumor mice without restrain.Conclusion:Restraint stress aggravates the depression of the immune function of mice with S180 tumor and promotes the growth of the tumor.
