The dynamic change in the membrane protein on platelet microparticles of myocardial nifarction patient treated with Ticlid
- VernacularTitle:噻氯匹啶对心肌梗死患者血小板微粒膜蛋白动态变化的影响
- Author:
Yulong CONG
;
Xinli DENG
;
Xiangmin SHI
;
Zongjian YIN
- Publication Type:Journal Article
- Keywords:
Blood platelets;
Myocardial infarction;
Flow cytometry
- From:
Chinese Journal of Laboratory Medicine
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To approach the dynamic change in the membrane protein on platelet microparticles of patient with anti-platelet therapy, and look for a new test which are helpful to supervise the anti-platelet therapy. Method We collected blood samples from the patient with myocardial infarction ( n =9) treated with ticlopidine (250 mg?2 in the first and second day, 250 mg/day from the third to sixth day)in different time (before treatment, and 4 d, 5 d, 6 d, 9 d, 10 d after treatment), and examine the percent of PAC-1 + PMP or CD62p + PMP in the samples by activating platelet with 20 ?mol ADP. Result By activating platelet with 20 ?mol ADP, the percent of CD62p + PMP at different time (before treatment, and 4 d, 5 d, 6 d, 9 d, 10 d after treatment) were 84.3%?3.6%, 81.4%?3.4%, 70.3%?2.7%, 70.6%?3.2%, 83.5%?2.8%, 85.4%?2.1%,as of PAC-1 + PMP were 85.3%?3.5%, 82.5%?2.2%, 72.3%?3.5%, 72.4%?3.3%, 85.4?3.4%, 86.0%?3.8%. The percent of CD62p + PMP and PAC-1 + PMP in 5 d obviously increase ( P
