The correlation between genotypes at the position-889C/T in the promoter of interleukin-1 alpha and the severity of coronary heart disease
- VernacularTitle:白细胞介素1?基因启动子-889位点C/T基因型与冠心病严重程度的关系
- Author:
Yan LI
;
Pu XU
;
Pingan ZHANG
;
Xiaoyan LI
;
Congxin HUANG
- Publication Type:Journal Article
- Keywords:
Interleukin 1;
Gene;
Polymorphism;
Coronary heart disease
- From:
Chinese Journal of Laboratory Medicine
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the different genotypes at the position -889 in the promoter of interleukin-1 alpha(IL-1?) and the severity of coronary heart disease(CHD). Methods The genotypes of IL-1?(-889C/T)in 118 CHD patients and 184 healthy controls were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and The serum level of IL-1? was detected by enzyme-linked immunoabsorbent assay. Results The distribution of IL-1? (-889C/T) genotypes between myocardial infarction(MI) patients and healthy controls was significantly different (? 2=5.96, P
