Effect of 0.05% Cyclosporine A on the Ocular Surface after Photorefractive Keratectomy.
10.3341/jkos.2016.57.5.710
- Author:
Yong Il KIM
1
;
Sung Hyun KOO
;
Sang Won HA
;
Gwang Ja LEE
;
Kyoo Won LEE
;
Young Jeung PARK
Author Information
1. Cheil Eye Hospital, Daegu, Korea. eyepark9@naver.com
- Publication Type:Original Article
- Keywords:
Cyclosporine A;
Dry eye;
Ocular surface stability;
Photorefractive keratectomy;
Refractive surgery
- MeSH:
Cyclosporine*;
Fluorescein;
Humans;
Photorefractive Keratectomy*;
Refractive Surgical Procedures;
Retrospective Studies;
Tears;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2016;57(5):710-717
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the effect of 0.05% cyclosporine A on the ocular surface after photorefractive keratectomy (PRK). METHODS: This retrospective study included 50 patients who underwent PRK. Patients were divided into two groups: 25 patients in group I were treated with topical 0.05% cyclosporine A with conventional medication, and 25 patients in group II were treated with conventional medication. Visual acuity (VA), tear break-up time (BUT), fluorescein staining score (F-stain), Schirmer I test, and ocular surface disease index (OSDI) were evaluated before surgery and 2 weeks, 1 month, 2 months, and 3 months after surgery. RESULTS: F-stain was significantly lower in group I than in group II at 2 weeks and 1 month (p < 0.05). There was no significant difference in uncorrected VA, BUT, Schirmer I test, or OSDI between the groups. However, group I showed a more effective pattern in dry eye. CONCLUSIONS: Combination treatment with 0.05% cyclosporine A was helpful for early ocular surface stability in patients with dry eye after PRK.
