The protective effects of estrogen on cerebral ischemia-reperfusion injury in rat
- VernacularTitle:雌激素对大鼠脑缺血-再灌注损伤的保护作用的研究
- Author:
Yun JIANG
;
Guanghui CHEN
;
Bo WU
- Publication Type:Journal Article
- Keywords:
Estrogen Cerebral ischemia reperfusion injury Neuroprotection
- From:
Journal of Clinical Neurology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effect of estrogen on cerebral ischemia reperfusion injury in rat Methods 120 adult female rats were randomly divided into the intact, ovariectomized(OVX),OVX and estrogen(E 2) replacement groups In the OVX+E 2 group, E 2 valerate(200 ?g/kg) was subcutaneousely injected once a week after the OVX Four weeks after the OVX, all rats were subjected to model of ischemia reperfusion by MCAO Infarct volumes were measured.Pathological changes and apoptosis was detected, and serum estrogen concentration was analyzed Results For different time of ischemia reperfusion,cerebral infarct volume in the OVX+E 2 group was minimal,and in the OVX group was maximal(all P
