Expression of heat shock protein 70 and its significance in cerebral ischemic tolerance induced by focal ischemic preconditioning in rats
- VernacularTitle:大鼠局灶缺血预处理诱导的脑缺血耐受中热休克蛋白70的表达及其意义
- Author:
Yuman HAO
;
Zuming LUO
;
Dong ZHOU
- Publication Type:Journal Article
- Keywords:
Ischemic preconditioning Ischemic tolerance Cerebral ischemia Heat shock proteins
- From:
Journal of Clinical Neurology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of focal ischemic preconditioning on the expression of heat shock protein 70(HSP70) and ischemic tolerance Methods 42 SD rats were divided into 3 groups in which control group received sham operation only, and the other two groups received 2 hours of middle cerebral artery occlusion(MCAO) followed by 22 hours of reperfusion with or without 10 minutes of ischemic preconditioning 3 days before Infarct volume and HSP70 immunoreactivity were evaluated in each group Results Compared with the sham operated group, there was a smaller infarct volume( P
