Cultured homologous dermal fibroblasts of rabbit in aPVR animal model
- VernacularTitle:利用培养的同种异体皮肤成纤维细胞制作aPVR动物模型
- Author:
Baichen LIU
;
Maonian ZHANG
;
Xiujun PENG
;
Tiechen LIU
- Publication Type:Journal Article
- Keywords:
Anterior proliferative vitreoretinopathy;
Fibroblasts;
Animal model
- From:
Journal of Medical Postgraduates
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To establish animal model of anterior proliferative vitreoretinopathy (aPVR) with cultured homologous dermal fibroblasts of rabbit, and to provide evidence why hypotony was caused by aPVR. Methods:Animal models of aPVR were established with cultured homologous dermal fibroblasts on pigmented rabbits. Rabbits were sacrificed on the 14th, 28th and 56th day after the operation to prepare naked eyes and to receive histological examinations. Results:Naked eye examination showed that the peripheral retina was detached by dragging in the experimental group 28 and 56 days postoperatively. Microscopic examination showed atrophy or absence of the non-pigmented ciliary epithelium on the 28th and 56th postoperative day in the experimental group. Conclusions:The epiciliary membrane in aPVR dragged the ciliary body, made atrophy of non-pigmented epithelium, which perhaps was the main cause of hypotony.
