Relation of the Amount of Circulating Endothelial Cells in Peripheral Blood and the Serum Level of VEGF in Tumor Patients
- VernacularTitle:肿瘤患者外周血循环血管内皮细胞数量与血清VEGF水平的关系
- Author:
Hui LI
;
Peng ZHANG
;
Xiubao REN
;
Hong LIU
;
Xishan HAO
- Publication Type:Journal Article
- Keywords:
tumor;
circulating endothelial cells (CECs);
circulating endothelial precursors (CEPs);
vascular endothelial growth factor (VEGF)
- From:
Chinese Journal of Cancer Biotherapy
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To analyze the circulating endothelial cells (CECs) and circulating endothelial precursors (CEPs) in peripheral blood of tumor patients. Methods: CECs and CEPs were enumerated in 57 tumor patients and 15 healthy controls by 3-color flow cytometry. The serum level of angiogenesis related cytokines(VEGF, bFGF)was determined by ELISA method. Results: In tumor patients, mean value of CECs and CEPs was (0.378?0.047)% and (0.059?0.013)% respectively. The serum level of VEGF and bFGF were (295.58?59.56) ng/L and (28.73?7.40) ng/L. The amount of CECs/CEPs positively correlated with the serum level of VEGF and bFGF. Conclusions: The CECs/CEPs and serum level of VEGF and bFGF of tumor patients was higher than those of normal controls. VEGF and bFGF may participate into the course of endothelial progenitors mobilization.
