The tolerance of focal cerebral ischemia and astroglial reaction
- VernacularTitle:局灶性脑缺血耐受和星形胶质细胞反应
- Author:
Yanqiu DENG
;
Gang ZHAO
;
Zhuomin JIAO
- Publication Type:Journal Article
- Keywords:
Ischemic precondition Focal cerebral ischemia Brain infarction Ischemic tolerance Astroglia
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective role of transient focal ischemic precondition(PC) against permanent focal cerebral ischemia, to define the proper time dose for precondition, and to study the reaction of astroglia in cerebral ischemic tolerance. Methods Temporary middle cerebral artery occlusion(10 minutes, 20 minutes, 30 minutes) followed three day reperfusion before permanent middle cerebral artery occlusion(PMCAO) transcranially was used as precondition in Wistar rats. The protective role was evaluated by observing the neurological deficits, analyzing the infarct volume and studying changes of pathohistology. The reaction of astroglia was observed by using anti GFAP immunohistochemistry.Results Compared with the control group, 20 min ischemic precondition, which did not produce neuronal damage obviously, alleviated the neurological deficits and reduced the infarct volume significantly( P
