The effect of calcitonic gene-related peptide and endothelin on acute and delayed cerebral vasospasm in experimental subarachnoid hemorrhage
- VernacularTitle:降钙素基因相关肽及内皮素在实验性蛛网膜下腔出血后急性与迟发性脑血管痉挛中的作用
- Author:
Wei SHEN
;
Shaozu YU
;
Huayan FAN
- Publication Type:Journal Article
- Keywords:
Subarachnoid hemorrhage Cerebral vasospasm Calcitonic gene related peptide Endothelin
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of calcitonic gene related peptide(CGRP) and endothelin(ET) on acute and delayed cerebral vasospasm(CVS) after subarachnoid hemorrhage(SAH).Methods The SAH model in rabbit were established by single injection of autologous arterial blood(0.5 ml/kg) to cisterna magna on percutaneous suboccpital route. Transcranial Dopper(TCD) was performed to detect the spastic of rabbit basilar artery(BA). The CGRP and ET concentrations in cerebrospinal fluid were examinated quntitatively by radioimmunologlc techniques at 30 minutes, 3 days, and 5 days after SAH.Results The results of TCD showed that rabbit basilar artery was spastic at 30 minutes, 3 days and 5 days after SAH. At 30 minutes after SAH, CGRP concentration significantly increased upto about 18 fold( P
