Effects of flunarizine on contents of SOD、MDA、NO、NOS in serum and brain tissue and pathological changes in gerbils of ischemia- reperfusion cerebral injury
- VernacularTitle:西比灵对鼠脑缺血再灌注损伤模型的血清及脑组织中SOD、MDA、NO、NOS含量及病理学的影响
- Author:
Aihua WANG
;
Qiuling ZHANG
;
Yizhao LI
- Publication Type:Journal Article
- Keywords:
Ischemia-reperfusion Free radicals SOD Flunarizine
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of flunarizine on the contents of SOD、 MDA、 NO、 NOS in serum and brain tissue and pathological changes in gerbils of ischemia-reperfusion cerebral injury. Methods Twentyone gerbils were randomly divided into three groups: ischemia-reperfusion group, flunarizine pretreatment group and control group. There were seven gerbils in each group. The levels of SOD, MDA, NO and NOS in the serum and brain tissue were determined, and pathological changes of brain were observed by microscopy. Results It was found that the group of ischemia-reperfusion had characteristic changes of ischemia-reperfusion injury. Compared with the control group, serum and brain contents of MDA, NO and NOS were higher but the content of SOD was lower,and the differences were significant(all P
