Efficacy of Naphthoquine, Artemisinine and a Combination of the Two Drugs in the Treatment of Falciparum Malaria
- VernacularTitle:复方萘酚喹及其组分单药治疗恶性疟的临床研究
- Author:
Jingyan WANG
;
Chengqi SHAN
;
Dadong FU
;
Zhiwei SUN
;
Deben DING
- Publication Type:Journal Article
- Keywords:
drug combination, naphthoquine, artemisinine, treatment, falciparum malaria
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy and safety of naphthoquine, artemisinine and a combination of the two drugs in the treatment of faciparum malaria. Methods Of 230 patients, 100 patients were treated with combined regime (Co-NQ), 100 patients were treated with naphthoquine (NQ) and 30 patients were treated with artemisinine (QHS). All patients were hospitalized for 7 days and followed up for 28 days. Results The mean fever clearance time for Co-NQ, NQ, and QHS was (17.5 ?12.3)h, (32.7?17.7)h and (18.1?9.7)h respectively; the mean parasite clearance time was (30.0?8. 8)h,(45.5?10.0)h and (29.1?6.0)h respectively; and the 28 days cure rate was 97.0% ,100.0% and 66.7% respectively. Conclusion The Co-NQ possesses benefits of both naphthoquine and artemisinine, acting rapidly, with a short course of only one dose and a high cure rate. The regime is well tolerated by patients.
