The rapid prediction of GVHD by three-dimensional structure differences of HLA
- VernacularTitle:利用供受体HLA三维结构差异快速预测GVHD
- Author:
Hongxing HAN
;
Fanhua KONG
;
Yongzhi XI
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem cell transplantation;
GVHD;
HLA three-dimensional structure
- From:
Chinese Journal of Blood Transfusion
1988;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Trying to predict the degree of GVHD after partly matched hematopoietic stem cell transplantation. Methods Analysis of the relationship between three-dimensional structure differences of donor-patient unmatched HLA and the GVHD levels after hematopoietic stem cell transplantation. Results GVHD levels were related to donor-patient unmatched HLA structure differences. The HLA structure differences forⅠ - Ⅱ degree GVHD were much smaller than that for Ⅲ - Ⅳ degree GVHD. Conclusion Prediction of GVHD by HLA structure differences is simple, rapid, specific and could help select proper conditioning regimens before transplantation and the proper immune suppressive agents after transplantation.
