Preparation of medical chitosan microspheres improved with polyvinyl alcohol and its adsorption test of blood lipids
- VernacularTitle:聚乙烯醇改性医用壳聚糖微球的制备及其血脂吸附实验
- Author:
Xunming HUANG
;
Min WANG
;
Liangmin HUANG
- Publication Type:Journal Article
- Keywords:
chitosan;
polyvinyl alcohol(PVA);
medical microsphere;
adsorption;
LDL
- From:
Chinese Journal of Marine Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare medical chitosan microspheres used in blood lipid adsorption. Methods Medical chitosan microspheres were prepared by suspending chitosan in liquid paraffin, adding proportional glutaraldehyde as crosslinking agent and a small amount of polyvinyl alcohol(PVA) to improve its flexibility. The blood lipid adsorption v/ere studied in a dynamic way. Results The medical chitosan microspheres containing a small amount of PVA were more effective in decreasing the contents of cholesterol(CH) , triglyceride(TG) , LDL in human serum. Conclusion The chitosan microspheres obtained by adding a small amount of PVA could be used as a desirable medical microsphere in the adsorption of blood lipids.
