Effects of levodopa on the serum excitatory amino acids and anti-oxidative indexes in rats with Parkinsonism
- VernacularTitle:左旋多巴对帕金森病大鼠血清兴奋性氨基酸及抗氧化指标的影响
- Author:
Qin XIAO
;
Zhongfang WENG
;
Jing ZHANG
- Publication Type:Journal Article
- Keywords:
Levodopa Parkinson's disease Excitatory amino acids Anti oxidative system
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of levodopa on the serum excitatory amino acids and some anti oxidative indexes in rats with parkinsonism.Methods Different doses of levodopa/benserazide were treated orally for three months in rats with 6 OHDA induced partial or severe injuries of unilateral nigrostriatal pathway. The levels of serum aspartic acid, glutamate and glutamine were measured by high performance liquid chromatography(HPLC). Serum superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH) and glutathione peroxidase (GSH PX) were detected.Results After the rats were treated with levodopa,the concentration of serum aspartic acid was significantly increased in the severely 6 OHDA lesioned rats ( P
