Study on the effect of nitric oxide synthase inhibitor on the learning and memory abilities in rats and the effect of nimodipine
- VernacularTitle:一氧化氮合酶抑制剂对大鼠学习记忆能力的影响及尼莫地平的作用研究
- Author:
Hongzhi GUO
;
Wanliang DU
;
Chuanqiang QU
- Publication Type:Journal Article
- Keywords:
Nitric oxide synthase inhibitor Learning Memory Nitric oxide Nimodipine
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of nitric oxide synthase inhibitor on learning and memory abilities and to observe the change of nitric oxide (NO) contents in the hippocampi and the effect of nimodipine in rats.Methods With the administration of L ? nitro L arginine(L NA) into bilateral hippocami,the rat model with disorders of learning and memory abilities was established.Then the intraperitoneal injections of nimodipine were given, Y maze tests were performed, and the NO contents in the hippocampi were measured in turn.Results The experiment showed that the learning and memory abilities of model and intervention rats were worse than those of the control rats ( P
