The study of effective regions of estrogen in brain of convulsive rats
- VernacularTitle:雌激素致癇作用部位的研究
- Author:
Fushan GUO
;
Zhaofu CHI
;
Hongjun ZHANG
- Publication Type:Journal Article
- Keywords:
KA Flurothyl Estrogen Epilepsy FOS
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the effective regions of estrogen in central nervous system of convulsive rats.Methods In two models of epilepsy with different mechanism induced by Kainic acid(KA) and flurothyl, we observed FOS expression of hippocampus, cerebral cortex and corpus striatum in the rats of convulsive group with and without estradiol (E 2) administration by means of immunohistochemistry.Results In the rats of convulsive group induced by KA and flurothyl, the FOS expression in hippocampus, cerebral cortex and corpus striatum was significant higher than those of normal control group (all P 0.05).Conclusion The FOS expression of rats'brains induced by E 2 is different in two models of epilepsy with different mechanism.
