Experiment and clinical study of up-regulation effect of captopril on the platelet nitric oxide synthase activity in patients with ischemic stroke
- VernacularTitle:卡托普利上调缺血性脑卒中患者血小板一氧化氮合酶的实验和临床研究
- Author:
Zhuang WANG
;
Jianfang HE
;
Yibai XU
- Publication Type:Journal Article
- Keywords:
Cptopril Ischemic stroke Nitric oxide sythase
- From:
Journal of Clinical Neurology
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the up regulation of captopril on the platelet nitric oxide(NO) synthase and clinical application in patients with ischemic stroke.Methods The washed platelets in vitro of the patients with acute ischemic stroke and healthy controls were added with oxidized LDL(oxLDL) and captopril followed by measurement of platelet NO synthase activity.Plasma oxLDL,NO sythase,NO and platelet NO sythase,NO in 40 patients were measured before oral captopril and after oral captropril 1 month,3 months.Results (1)After the washed platelets in vitro were added with oxLDL,the platelet NO synthase activities of the patients and controls were all significantly decreased( P
