Behavior Index of Two Morphine Dependent Models of Mice
- VernacularTitle:两种吗啡依赖小鼠模型的行为学及相关指标的对比研究
- Author:
Hongwan LI
;
Jie WEI
;
Yinguo ZHANG
- Publication Type:Journal Article
- Keywords:
psychiatry substance dependence and abuse animal study behavior animal model morphine
- From:
Chinese Mental Health Journal
1991;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the interaction of withdrawal behaviors and correlated indices of two morphine dependent models of mice.Method: Mice were given morphine with gradual increasing dose to establish two models of morphine dependence with different dosage sequence, i.e. model 1 for 7 days, model 2 for 5 days. Withdrawal syndrome was precipitated by naloxone and recorded. The weight of heart, liver, lung, kidneys, adrenal glands, testicles of the mice were compared.Result:Both methods (7 days way and 5 days way) successfully established morphine dependent models in mice. In withdrawal, the mice of 7 days model had more average times of jump and “wet-dog” shaking than the mice of 5 days model had, they had also more obvious upper eyelid dropping and anterior claw tremble. The weights of heart, kidneys, testicles of the mice of 7 days model were significantly lower than the counterparts of the mice of 5 days model. Conclusion:Both 7 days way and 5 days way can establish morphine dependent model of mice, the former has advantage of more indexes applicable while the later has advantage of less dose of morphine and short time needed.
