Dynamic variation of HCV hypervariable region gene and homology analysis
- VernacularTitle:HCV高变区基因变异的动态观察及同源性分析
- Author:
Xun WANG
;
Lan ZHENG
;
Liping XU
- Publication Type:Journal Article
- Keywords:
Hepatits C virus;
High variable region;
Gene variation;
Genotype;
Transfusion
- From:
Chinese Journal of Blood Transfusion
1988;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find out the dynamic variation on HCV genome to give the theoretic basis for diagnosis of post transfusion hepatitis C,and demonstrate the causality between donors and recipients suffering from post transfusion hepatitis C.Methods The high variable envelope gene fragments (HVR1 and HVR2) of HCV was selected for a cross sectional study and a one year follow up study was carried out on 3 HCV patients at every 3 month period to understand the dynamic variation of HCV HVR in each patient.Results The homology of HCV HVR genes among different types is 56.99%～60.88%,65.09%～68.80% among different subtypes,and 80.05%～96.40% among the same subtypes.It consists with the geographic distribution of HCV.The homology between the different strains isolated from the same patients is 92.10%～99.73%,95.36%～97.54 and 97.07%～99.20%,respectively.Conclusion The variation of different HCV strains in HVR is great.However,the variation of the same virus in the same patient during short infectious period is rather limited,which is no more than 7.9% per year.So the transmission pathway of some hepatitis C cases can be trailed at the molecular level by this way,and some non transfusion transmitted hepatitis C cases can be exclude
