Adenovirus-mediated HCY2 induces apoptosis in vascular smooth muscle cells
- VernacularTitle:腺病毒介导的HCY2基因对血管平滑肌细胞凋亡的诱导作用
- Author:
Qian LI
;
Yanhong GUO
;
Mingjuang QU
- Publication Type:Journal Article
- Keywords:
Smooth muscle cell;
Apoptosis;
Adenovirus
- From:
Chinese Journal of Interventional Cardiology
1993;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate roles of Homocysteine induced gene HCY2 in vascular smooth muscle cells (VSMC) Methods HCY2 was delivered into VSMC by replication defective adenovirus DNA fragmentation was investigated by DNA Laddering and cell death ELISA VSMC in sub G1 was detected by using flow cytometry Results DNA from VSMC transfected by HCY2 gene was cleaved into multiple nucleosomes and VSMC in sub G1 region increased after being infected with HCY2 Conclusion HCY2 is able to induce apoptosis in VSMC
