Clinical significance of breast cancer resistance protein mRNA in patients with cervical cancer
10.3760/cma.j.issn.1006-9801.2013.11.009
- VernacularTitle:子宫颈癌中乳腺癌耐药蛋白mRNA的表达及其临床意义
- Author:
Fengmei YANG
;
Guangling GUO
;
Fen CHEN
;
Liping ZHANG
;
Bo GAO
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Resistance protein;
Uterine cervical neoplasms;
RNA,messenger
- From:
Cancer Research and Clinic
2013;25(11):754-755,762
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mRNA expression of breast cancer resistance protein (BCRP) in cervical cancer (CC).Methods The expression of BCRP mRNA was detected by real-time PCR from tissues of 12 normal and 47 cases with CC.Results The expression of BCRP mRNA was 0.59±0.26 in CC and 0.19±0.17 in normal cervical tissues.But it was significantly higher in CC than those in normal tissues (P ＜ 0.05).The expression of BCRP mRNA was not correlated with histological types,tumor differentiation degree and clinical stages (P ＞ 0.05).Conclusion BCRP mRNA over-expresses in CC,wich might play a major role in the intrinsic MDR of CC.Detection of BCRP mRNA expression may the guidance of individualized chemotherapy for patients with CC.
