The changes of NO, NOS, ET content in plasma after acute cerebral infarction and the therapeutic effect of nimodipine on them
- VernacularTitle:急性脑梗死后血浆NO、NOS、ET含量的动态变化及尼莫地平对其影响
- Author:
Wenwei YUN
;
Juxiang LIN
;
Yin CAO
- Publication Type:Journal Article
- Keywords:
Cerebral infarction NO NOS ET Change Nimodipine
- From:
Journal of Clinical Neurology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of nitric oxide(NO), nitric oxide synthase(NOS),and endothelin(ET) contents in plasma after acute cerebral infarction(ACI), And to evaluate the therapeutic effect of nimodipine on their changes.Methods 110 cases with ACI were randomly divided into Nimodipine therapeutic group(Nimodipine is used with general therapy,Nimodipine group) and general therapeutic group(general group). NO, NOS and ET contents in plasma at different time after ACI were observed, while control group was set up.Results ET content in plasma after ACI increased significantly until recovery. NO and NOS contents in plasma rise at the beginning, then they declined. ET contents had significant difference between Nimodipine group and general group( P 0.05).Conclusion NO, NOS and ET interfered with the complex process of pathologic after acute cerebral infarction. Nimodipine had therapeutic action on ACI partly depended on affecting content of ET in plasma.
