Effcets of interferon-? and octreotide on GH-secreting pituitary adenoma
- VernacularTitle:?-干扰素和奥曲肽对垂体生长激素腺瘤的作用
- Author:
Jie LI
;
Jixin SHI
;
Handong WANG
- Publication Type:Journal Article
- Keywords:
GH secreting pituitary adenoma Cell culture Hormone secretion Interferon ? Octreotide
- From:
Journal of Clinical Neurology
1992;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of IFN ? and Somatostatin analog octreotide (SMS) on hormone secretion by cultured human GH secreting pituitary adenomas.Methods Each cultured GH secreting pituitary adenoma cells were equally distributed to culture tube and divided into 4 groups: control, IFN ?, SMS, and IFN ?+SMS. Different drugs were added into different groups. The hormone secretion in each group were detected after 2 and 4 days' incubation.Results After 2 and 4 days' incubation with IFN ?(100 IU/ml) GH secretion was significantly inhibited in 6 of 10 and 7 of 10 pituitary adenoma cultures ,reduced by 22%～54% and 30%～61% vs control ( P
