Huo-Luo-Xiao-Ling-Dan Plays a Protective Role in Ischemic Brain in Rats via Inhibiting Inflammatory Responses after Stroke
- VernacularTitle:活络效灵丹通过抑制脑组织炎症反应对缺血性脑损伤的保护作用
- Author:
Zhuqing JIN
- Publication Type:Journal Article
- Keywords:
ischemic stroke;
Huo-Luo-Xiao-Ling-Dan;
middle cerebral artery occlusion(MCAO);
TNF-α;
IL-1β
- From:
Journal of Zhejiang Chinese Medical University
2013;(9):1099-1102,1107
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To observe whether Huo-Luo-Xiao-Ling-Dan(HLXLD) can inhibit the inflammation after ischemic stroke. [Methods] Focal cere-bral ischemia was induced by middle cerebral artery occlusion (MCAO) for 2 hours fol owed by 24 or 48 hours reperfusion in male rats. We treated is-chemic stroke rats with HLXLD(0.5, 2.0 and 6.0g·kg-1) by daily gavages beginning at the onset of stroke. The control group received the vehicle. [Re-sults] HLXLD 2.0, 6.0/kg treatment significantly attenuated the infarct volume, neurological deficits, upregulation of proinflammatory cytokines in the brain of rats after stroke compared with that of non-HLXLD group. Furthermore, the activation of NF-κB signaling was significantly reduced in HLXLD treated rats after stroke compared to that of non-HLXLD group. [Conclusion] Our data demonstrated that HLXLD can play an important protective role in brain injury after ischemic stroke via inhibiting inflammatory responses in the brain.
