Association study of cirrhosis and IL-12B gene polymorphism*
10.3969/j.issn.1671-8348.2013.24.001
- VernacularTitle:IL-12B基因多态性与肝硬化易感性的关联研究
- Author:
Weifeng ZHAO
;
Gaoling GU
;
Jingpei DU
;
Changan LI
;
Qian DOU
;
Changyu SUN
- Publication Type:Journal Article
- Keywords:
cirrhosis;
IL-12B;
polymorphism;
association analysis
- From:
Chongqing Medicine
2013;(24):2825-2826,2831
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the genetic association between cirrhosis and polymorphism of IL-12B gene .Methods Observed in a sample of 173 parent/offspring trios where the proband net for cirrhosis using correlation analysis and haplotype relative risk a-nalysis .The polymorphism of rs15677380 ,rs14050311 of IL-12B gene was detected with PCR methods and SNP typing in all nucle-us families .Results The rs15677380 allele was connected with cirrhosis(P=0 .009) .Allele G was protect factor(Z= -2 .36) and allele A was the hazard factor(Z=2 .36) .The rs14050311 allele was connected with cirrhosis(P=0 .013) .Allele T was protect fac-tor(Z= -2 .24) and allele C was the hazard factor (Z=2 .24) .The haplotypes of G/T and A/C in the rs15677380 ,rs14050311 were associated with cirrhosis (P=0 .021 ,0 .015 ,Z= -1 .85、2 .16) .Conclusion It shows an association between cirrhosis and the poly-morphism of IL-12B gene in Chinese .
