Study on anti-apoptosis effect of focal cerebral ischemic preconditioning in rats
- VernacularTitle:大鼠局灶性脑缺血预处理的抗细胞凋亡作用机制的研究
- Author:
Gang ZHAO
;
Yanqiu DENG
;
Zhuomin JIAO
- Publication Type:Journal Article
- Keywords:
Ischemic preconditioning Cerebral ischemia Neuronal apoptosis bcl 2 Bax
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effect on transient focal cerebral ischemic preconditioning against neuronal cell apoptosis again,and the relationship between bcl 2, bax and cerebral ischemic tolerance.Methods Middle cerebral artery occlusion (MCAO) was showed for 20 min by craniotomy and MCA was blocked 6 h after 3 d.Cerebral infarct volume and the change of histopathological in rats were observed,the status of neuronal cell apoptosis were observed by TUNEL mothod,the alteration of bcl 2 and bax protein expression were observed by immunohistochemical method.Results As compared with the false preconditioning group and ischemia group,the infarct volume in the ischemic group reduced significantly after preconditioning( P
