Study on treatment effect of Sibelium to cerebral vascular lesion of hypertension
- VernacularTitle:西比灵对大鼠高血压性脑血管病变作用的研究
- Author:
Ruxun HUANG
;
Qingchun GAO
;
Jinsheng ZENG
- Publication Type:Journal Article
- Keywords:
Hypertension Sibelium Cerebrovascular pathology
- From:
Journal of Clinical Neurology
1997;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To probe into the treatment effect of Sibelium to hypertensive cerebral vascular lesion and its mechanism.Methods After preparing the model of renovascular hypertensive rats (RHR), we observed the changes of the arterial blood pressure, the cerebral blood velocity, and the pathology of cerebral vascular with treatment of Sibelium. Results The arterial blood pressure of the rats taking medicine 2 to 4 weeks later was lower obviously than RHR of no taking medicine at the same stage, The pathological changes of basal cerebral arteries in the rats were milder than RHR of no taking medicine after treating 4 to 6 weeks. These effects may keep 2 to 4 weeks.Conclusion At early stage of hypertension,Sibelium can reduce the arterial blood pressure of RHR, and stop the progress of cerebral vascular lesion.
