Effects of the fucoidan from Cladosiphon okamuranusa on Sar-coma_(180)-bearing mice
- VernacularTitle:枝管藻Cladosiphon okamuranusa多糖对荷S_(180)小鼠的作用
- Author:
Jingfeng WANG
;
Xuecheng ZHANG
- Publication Type:Journal Article
- Keywords:
Cladosiphon okamuranusa fucoidan (CF);
sarcoma 180(S180);
Spleen index;
Thymus index;
Malondialdehyde(MDA);
Superoxide dismutase(SOD)
- From:
Chinese Journal of Marine Drugs
2000;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective Effects of fucoidan from Cladosiphon okamuranusa (CF)on mice bearing Siso were investigated. Methods Different concentrations of CF were given to mice bearing tumor by ig. The tumor weight, spleen index, thymus index and serum MDA content, serum SOD activity were detected by physical and biochemical methods. Results The growth of S180 tumor was inhibited significantly by CF in different concentrations. The inhibitory rate ranged from 27. 83% to 33. 97%. The highest inhibition rate occurred in the medium dosage. The spleen index, thymus index and leukocyte counts were not influenced obviously. The content of serum MDA was decreased remarkably and the activity of serum SOD was enhanced notably. Conclusion The mechanism of anti -tumor effects of CF may relate with its antioxidation.
