The protective effects of OLA-PENa on experimental liver injury in rats
- VernacularTitle:齐酞酸钠对大鼠实验性肝损伤的保护作用
- Author:
Lei WAN
;
Xiufen CHEN
;
Zhaohui JIANG
- Publication Type:Journal Article
- Keywords:
OLA-PENa (oleanolic acid 3β-phthalic monoester disodium salt);
experimental hepatic injury
- From:
Chinese Pharmaceutical Journal
1998;(2):80-
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the protective effects of OLA-PENa on experimental hepatic injury in rats and compare it with OLA in the dose-response relationships. METHODS: Biochemical indexes and histopathological examination of hepatic injury in rats caused by toxicant chemicals ［D-galactosamine (D-Galn) and CCl4］ were determined. RESULTS: OLA-PENa obviously inhibited the rising of serum alanine transaminase (ALT) caused by D-Galn and CCl4 and dramatically decreased liver fat storage as well in a dose-dependent manner. Histopathological examination showed that OLA-PENa can evidently alleviate the condition of the degeneration of hepatic cells and that of necrosis. CONCLUSION: The protective effects of OLA-PENa on experimental liver injury in rats, all the mentioned effects, are more powerful than those of OLA with the same dosage.
