Effects on Amyloid-? protein in extracellular monamine neurotransmission of frontal cortex and hippocampus in rats
- VernacularTitle:?淀粉样蛋白对大鼠额叶和海马细胞外液单胺类递质的影响
- Author:
Chunfeng LIU
;
Yongping DAI
;
Shiyao BAO
- Publication Type:Journal Article
- Keywords:
Amyloid ? protein Monamine neurotransmissions Nimodipine Rat
- From:
Journal of Clinical Neurology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the neurotoxicity of A? and monoamine neurotransmissions in brain.Methods 32 male SD rats were divided into four groups: The model group, Nimodipine treatment group, Shenmai treatment group and the control group,there are 8 rats in each group.Under the stereotaxis A? was injected into NBM of rats to establish AD model, The extracellular monoamine neurotransmissions were detected by microdialysis in vivo with high performance liquid chromatography.Results The contents of frontal lobe NE,DA,5 HT in the model group were lower than those in the control group, which recovered to normal level,DA in hippocampus was higher than the control group;after the treatment of Shenmai,the result was similar to Nimodipine group.There was no difference between the two treatment groups.The rising levels of three kinds of transmitters in different brain area were different.Conclusion Neurotoxicity of A? might relate to dysfunction in monoamine system. A? on monamine system of inhibition was shown through multiple pathways, including the loss of Ca 2+ homeostasis.
