Study on contents of neuron amino acid in epilepsy rat's hippocampus
- VernacularTitle:致痫大鼠海马神经元氨基酸类物质含量变化的研究
- Author:
Renshi XU
;
Yuanyuan HU
;
Hong ZHANG
- Publication Type:Journal Article
- Keywords:
Epilepsy Amino acid Neurotransmitter Pathogenesis mechanism
- From:
Journal of Clinical Neurology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the synthesizing and secretion of hippocampus neuron amino acid on epilepsy, and explore the pathogenesis of epilepsy attack.Methods We treated culturing hippocampus neuron cell in rats by coriaria lactone(CL), and measured the contents of glutamate(Glu), asparte(Asp), gama aminobutyric(GABA) and glycocine(Gly) of the internal and external culturing hippocampus neuron cell by high performance liquid chromatography(HPLC).Results The Glu synthesizing of epilepsy hippocampus neuron cell increased relatively, the Glu secretion increased significantly( P 0 05), or decreased relatively, the secretion increased significantly( P
