Protection of the neurons and improvement of the cognitive function after transient global forebrain ischemia attack in NJS mice used batroxobin
- VernacularTitle:巴曲酶对NJS小鼠短暂性脑缺血发作后神经细胞的保护和改善认知功能的作用
- Author:
Zhiqiang GAO
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia Batroxobin Apoptosis Congnitive function
- From:
Journal of Clinical Neurology
2001;0(05):-
- CountryChina
- Language:Chinese
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Abstract:
Objective To observe protection of the neurons and improvement of the cognitive function after transient global forebrain ischemia attack(TIA) in NJS mice used batroxobin.Methods 56 NJS mice were divided into four groups: control group (ischemia attack group, but no using batroxobin), batroxobin group used 2 hours before ischemia attack, batroxobin group used 2 hours after ischemia attack and batroxobin used 24 hours after ischemia attack. The scores of cognitive behavior and the numbers of neuron apoptosis in CA 1 of hippocampus were estimated 72 hours after ischemia attack.Results The numbers of neuron apoptosis were fewer and the cognitive function was better in the group used batroxobin 2 hours before and after ischemia attack; the scores of the scales in the group used batroxobin 24 hours after ischemia were not different as compared with the control group.Conclusion Batroxobin can reduce the numbers of neuron apoptosis and promote the recovery of congnitive function in NJS mouse after TIA,but it should be used in the early stage after TIA.
