Study on the mechanism of laminarin sulfate in the prevention of experimental atherosclerosis
- VernacularTitle:褐藻淀粉硫酸酯对实验性动脉粥样硬化预防作用的机理研究
- Author:
Xuguo LIANG
;
Xiaoxia DU
;
Qixing PAN
- Publication Type:Journal Article
- Keywords:
Laminarin sulfate;
Atherosclerosis;
Interleukins;
Tumor nercosis factor;
Immu-nologic function
- From:
Chinese Journal of Marine Drugs
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the possible immunological mechanism of laminarin sulfate in the prevention of experimental atherosclerosis. Methods Serum soluble interleukin 2 receptor (sIL-2R) , circulating immuno-complex, sub units of T lymphocyte, inter leukin-6(IL-6) , in-terleukin-8(IL-8), tumor necrosis factor-a (TNF-a) and lipid metabolism were determined by ELISA, RIA in rats and quails. Results The lipid metabolism and immunologic function were prominent disturbance in animals after feeding with high-lipid food. However, Laminarin sulfate has obvious regulating effects on above-mentioned index. Conclusions The mechanism of laminarin sulfate in the prevention of atherosclerosis might be closely related to the regulation of the disturbance of lipid metabolism and to the regulation of the immunologic function of the body.
