Study on correlation of Cytomegalovirus infection, endothelin and tumor necrosis factor with atherosclerosis in type 2 diabetes mellitus
- VernacularTitle:2型糖尿病动脉粥样硬化与巨细胞病毒感染及内皮素、肿瘤坏死因子的相关性研究
- Author:
Haixiang NI
;
Hong LI
;
Qi HUANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
Atherosclerosis;
Cytomegalovirus;
Endothelin;
Tumor necrosis factor
- From:Chinese Journal of Diabetes
2000;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between cytomegalovirus (HCMV) infection and atherosclerosis (AS) and explore the possible role of endothelin (ET) and serum tumor necrosis factor(TNF ?) in the pathogenesis of AS in diabetic patients and the relationship between HCMV infection and concentrations of ET and TNF ?. Methods Blood samples were collected from 21 patients with AS of type 2 DM, 47 patients with non AS of type 2 DM and 20 controls. Special antibodies to HCMV (IgM,IgG) were measured by enzyme linked immunosorbent assay (ELISA) . The concentrations of serum TNF ? and plasma ET were determined by RIA. Results (1) Type 2 diabetic patients, especially those with established AS, had a higher prevalence of active infection of HCMV. (2) The levels of plasma ET and serum TNF ? in type 2 diabetic patients were higher than those in normal people. In the pathogenesis of AS in diabetic patients, the ET played more important role than the TNF ?.(3) There was a significantly positive correlation between anti IgM to HCMV and the level of plasma ET in type 2 DM patients. It suggested that the injury of endothelium cell was related to the active infection of HCMV. Conclusion The study suggests that HCMV infection may be important in the pathogenesis of AS in type 2 diabetic patients and ET possibly plays an important role on the pathological course of AS.
