Study on the interference therapy of mild hypothermia and correlation between ICAM-1 expression and leukocyte infiltration on cerebral ischemia-reperfusion in rats
- VernacularTitle:大鼠脑缺血再灌注模型ICAM-1表达与白细胞浸润关系及亚低温干预治疗的研究
- Author:
Qian YANG
;
Wushen ZHU
;
Jiami WU
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia reperfusion Intercellular adhesion molecule 1 Leukocyte Mild to moderate hypothermia
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between the expression of intercellular adhesion molecule 1(ICAM 1) and leukocyte infiltration, and explore the effects of mild hypothermia.Methods ICAM 1 positive expression and leukocyte infiltration in the ischemic regions were determined using immunohistochemitry and histological HE staining techniques at different reperfusion time(2 h,8 h,24 h,48 h and 72 h) after middle cerebral artery occlusion (MCAO) for 3h in rats, and mild hypothermia was given after MCAO followed by 24h reperfusion.Results (1)The expression of ICAM 1 raised obviously 2h after cerebral ischemia reperfusion, and peaked at 24h ( P
