Antiradiation Effect of Marine Face Pack on the skin structure in Mice
- VernacularTitle:海洋生物面膜对小鼠皮肤的抗辐射作用研究
- Author:
Haiqing WANG
;
Lihua FANG
;
Xiaoping LIU
- Publication Type:Journal Article
- Keywords:
Marine Face Pack(MFP);
ultraviolet B;
Bcl-2;
NOS;
Antioxidants
- From:
Chinese Journal of Marine Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM protective effects of the Marine Face Pack (MFP) on hairless mice damaged by ultraviolet B(UVB) and it's relation to antioxidants were studied. MATHODS oxidative damage models of hairless mice irradiated by ultraviolet B (radiating intension; UVB 5. 15 ? 10-2J/cm2 ? 30 day) were established. The mice were randomly divided into four groups: control, UVB radiated groups (Water model, 10%MFP, 10%VitC). The ultrastructures of skin were observed by electromicroscope. The expression of Bcl - 2 protein and NOS were examined by immunohistochemical methods. The contents of MDA, the activities of GSH-Px, SOD and the T-AOC in the supernates of skin of those mice were detected by biochemical methods. RESULTS The large dilatant vacuolations and few rough endoplasmic reticu-lum in fibroblasts and epidermic cells of mice in UVB model group were observed under electromicroscope. MFP could keep the ultrastructure of epidermis and fibroblasts in the mice of MFP groups normal. MFP could enhance the expression of Bcl-2 protein and inhibit the ac-tivitiy of NOS(P
