Plasma tumor necrosis factor-? and insulin resistance in familial type 2 diabetes mellitus pedigrees
- VernacularTitle:2型糖尿病家系中血浆肿瘤坏死因子?水平与胰岛素抵抗
- Author:
Jing WU
;
Suhua ZHANG
;
Hongxin QIU
- Publication Type:Journal Article
- Keywords:
Tumor necrosis factor ?;
Insulin resistance;
Pedigree;
Diabetes mellitus,Type 2
- From:Chinese Journal of Diabetes
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study plasma tumor necrosis factor ?(TNF ?) level and its relationship with insulin resistance in familial type 2 DM. Methods Plasma TNF ? were determined by RIA in 32 familial type 2 DM patients, their 37 non diabetic first degree relatives and 40 healthy control subjects. Results Plasma TNF ? was significantly higher in familial type 2 DM patients[(1.19?0.21)?g/L] than in healthy control subjects[(1.00?0.18)?g/L]( P 0.05). Regression analysis indicated that TNF ? was inversely related to ISI and was a significantly independent contributor to variations in ISI. 39% of the variance in ISI was explained by TC, body mass index(BMI)and TNF ?. Conclusion The finding of an association between high plasma levels of TNF ? and insulin resistance suggests that TNF ? may be involved in the pathophysiology of insulin resistance in familial type 2 DM patients.
