Effect of mild hypothermia on neuronal apoptosis after transient global cerebral ischemia in rats
- VernacularTitle:亚低温对大鼠短暂全脑缺血后神经元凋亡的影响
- Author:
Shiyan CHEN
;
Zhijian ZHANG
;
Guoying XU
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia Apoptosis Mild hypothermia Rat
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the neuroprotective mechanism of mild hypothermia by studying the effect of mild hypothermia on neuronal apoptosis after transient global cerebral ischemia in rats.Methods A model of transient global cerebral ischemia was made by bilateral common carotid artery occlusion and hypotension in rats. The neuronal demage in the CA 1 section of the hippocampus after cerebral ischemia was observed by nissel body stain mothed;apoptosis was detected by in situ end-labeling of fragmented DNA using the terminal deoxynucleotidyl transferase reaction (TUNEL) and the electrical microscope.Results The hippocampal CA 1 section neurons in normothermic ischemic group were significantly deficit as compared with the false operative group in mild hypothermic ischemic group (P
