Effects of nicotine on GDNF and dopamine content in striatum of Parkinson's disease rats
- VernacularTitle:尼古丁对帕金森病大鼠纹状体GDNF和多巴胺含量的影响
- Author:
Xiaolin ZHU
;
Fei GUAN
;
Etang TONG
- Publication Type:Journal Article
- Keywords:
Nicotine Parkinson's disease GDNF DA
- From:
Journal of Clinical Neurology
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of nicotine on GDNF and dopamine content in striatum of Parkinson's disease (PD) rats.Methods 6-OHDA was stereoscopically injected to right side of the mesencephic ventral tegmental area (VTA) and substantia nigra pars compacta (SNpc). Nicotine of different dosages was intraperitoneally injected into PD rats.With biochemical,immunohistochemical techniques, we observed the changes of GDNF expression and dopamine content in striatum.Results Nicotine was intraperitoneally injected into PD rat models before or after the operation,striatum GDNF expression and DA content had significant improvement as compared with PD group (P
