Significance of combined determination of three autoantibodies in predictive of type 1 diabetes mellitus
- VernacularTitle:三种血清抗体联合检测1型糖尿病的预报价值
- Author:
Zhongcheng WANG
;
Zhulun ZENG
;
Quan LI
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus, insulin dependent;
Glutamatie acid decarboxylase;
Insulin autoantibodies
- From:
Chinese Journal of Laboratory Medicine
2001;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the significance of combined determination of glutamic acid decarboxylase antibodies(GADA),islet cell antibodies(ICA) and insulin autoantibodies (IAA) in predictive of type 1 diabetes mellitus Methods GADA, ICA and IAA were determined by enzyme linked immunosorbent assay and C peptide by radioimmunoassay Diagnose efficiency were calculated by matrix decision method Results The positive rate of GADA,ICA and IAA(68 8%,43 0% and 39 8%) were significantly elevated in the patients with type 1 diabetes mellitus compared with type 2 diabetes mellitus or normal subjects ( P
